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Keith R. Jerome

From Wikipedia, the free encyclopedia
Keith R. Jerome
EducationGeorgetown College
Duke University
Scientific career
FieldsVirology
InstitutionsUniversity of Washington

Keith R. Jerome is an American virologist whose research focuses on viruses such as herpes simplex, HIV and hepatitis B that persist in their hosts. He published on the first known case of COVID-19 in the United States detecting SARS-CoV-2 in Washington State[1] and helped forge the nation's COVID-19 testing.[2][3][4] In 2021, Jerome and Alexander Greninger shared the Washington Innovator of the Year award for developing the laboratory based assay for detecting COVID-19.[5] He was senior author on a research article published in Science describing the cryptic transmission of SARS-CoV-2 alongside Trevor Bedford, Alexander Greninger, Jay Shendure, and Helen Chu.[6] Regarding the origin of SARS-CoV-2 he reported that the live market in Wuhan was more likely than a lab leak of the virus.[7]

Jerome studies the ways in which these viruses evade the immune system and potential therapies for these infections. Jerome and his colleagues study the uses of precision gene-editing tools like CRISPR/Cas9 to remove damaging viral genes that have tucked themselves into a person's genetic code or to insert genes that can protect cells from invading viruses. He has been working for years on research aimed at a cure for Herpes virus by using the DNA-cutting tools of gene therapy. Initial research showed these techniques could knock out small quantities of latent virus.[8] He and his colleagues are exploring this approach in combination with blood stem cell transplants as a means of curing HIV.

Academic and medical appointments

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  • Professor, Department of Laboratory Medicine and Pathology, University of Washington, 2012–present
  • Head, Virology Division, Laboratory Medicine, University of Washington, 2012–present
  • Full professor, Fred Hutchinson Cancer Research Center, 2015–present

Education and training

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  • Georgetown College, B.S., Chemistry, summa cum laude, 1985
  • Duke University, PhD, Microbiology and Immunology, 1992
  • Duke University, MD, May 1993
  • Resident Physician, Department of Pathology, University of Washington, 1993-1995
  • Resident Physician, Department of Laboratory Medicine, University of Washington, 1995-1997
  • Senior Fellow, Virology Division, Department of Laboratory Medicine, University of Washington, 1997-1998

Selected publications

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References

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  1. ^ Bhatraju, Pavan K.; Ghassemieh, Bijan J.; Nichols, Michelle; Kim, Richard; Jerome, Keith R.; Nalla, Arun K.; Greninger, Alexander L.; Pipavath, Sudhakar; Wurfel, Mark M.; Evans, Laura; Kritek, Patricia A.; West, T. Eoin; Luks, Andrew; Gerbino, Anthony; Dale, Chris R.; Goldman, Jason D.; O'Mahony, Shane; Mikacenic, Carmen (May 21, 2020). "Covid-19 in Critically Ill Patients in the Seattle Region - Case Series". The New England Journal of Medicine. 382 (21): 2012–2022. doi:10.1056/NEJMoa2004500. PMC 7143164. PMID 32227758.
  2. ^ "How UW's Virology Lab Helped Forge the Nation's Covid-19 Testing". Seattle Met.
  3. ^ "When Coronavirus Struck Seattle, This Lab Was Ready To Start Testing". NPR.
  4. ^ Maxmen, Amy (March 6, 2020). "The race to unravel the biggest coronavirus outbreak in the United States". Nature. 579 (7798): 181–182. Bibcode:2020Natur.579..181M. doi:10.1038/d41586-020-00676-3. PMID 32152595. S2CID 212655031.
  5. ^ "Innovator of the Year awarded to directors of virology lab". newsroom.uw.edu. April 28, 2021.
  6. ^ Bedford, Trevor; Greninger, Alexander L.; Roychoudhury, Pavitra; Starita, Lea M.; Famulare, Michael; Huang, Meei-Li; Nalla, Arun; Pepper, Gregory; Reinhardt, Adam; Xie, Hong; Shrestha, Lasata; Nguyen, Truong N.; Adler, Amanda; Brandstetter, Elisabeth; Cho, Shari; Giroux, Danielle; Han, Peter D.; Fay, Kairsten; Frazar, Chris D.; Ilcisin, Misja; Lacombe, Kirsten; Lee, Jover; Kiavand, Anahita; Richardson, Matthew; Sibley, Thomas R.; Truong, Melissa; Wolf, Caitlin R.; Nickerson, Deborah A.; Rieder, Mark J.; Englund, Janet A.; Hadfield, James; Hodcroft, Emma B.; Huddleston, John; Moncla, Louise H.; Müller, Nicola F.; Neher, Richard A.; Deng, Xianding; Gu, Wei; Federman, Scot; Chiu, Charles; Duchin, Jeffrey S.; Gautom, Romesh; Melly, Geoff; Hiatt, Brian; Dykema, Philip; Lindquist, Scott; Queen, Krista; Tao, Ying; Uehara, Anna; Tong, Suxiang; MacCannell, Duncan; Armstrong, Gregory L.; Baird, Geoffrey S.; Chu, Helen Y.; Shendure, Jay; Jerome, Keith R. (October 30, 2020). "Cryptic transmission of SARS-CoV-2 in Washington state". Science. 370 (6516): 571–575. doi:10.1126/science.abc0523. PMC 7810035. PMID 32913002.
  7. ^ "UW Medicine's head of Virology: Live market 'more likely the start' of COVID". MyNorthwest.com. November 28, 2021.
  8. ^ Russell, Sabin (2020-08-18). "A cure for herpes? There is progress to report". Fred Hutch. Retrieved 2022-04-03.